Diabetics monkeys temporarily not need insulin injections more if they pancreases of pigs Embyronen be planted. The young donor organs to resist the stress of transplantation better than their adult counterparts. Researchers nourish the hope of a new therapy for diabetes.

Reisner is also a scientific consultant and partner in the biotechnology company Tissera, which supported the work financially, and explained in accordance with the statutes of the journal financial interest in the work.

Israeli researchers have monkeys in the pancreases of pigs can grow. The artificially made diabetic animals is needed occasionally, then no more insulin injections, report Yair Reisner from the Weizman Institute in Rehovot, and colleagues. The immune system of the experimental monkeys tolerated the foreign institutions also better than adult pig transplants, the researchers write in the "Proceedings" of the U.S. Academy of Sciences. They hope that this new therapeutic avenues for diabetics revealed that the shortage of human donor organs around it.

The team of four artificially Reisner transplanted diabetic primates of the species Macaca fascicularis pancreatic tissue 42 days old pig embryos. The early stage of development of the embryonic pancreas allowed the monkeys, the adolescent with their own bodies to pass through blood vessels and supply. That slowed the usual rejection reaction, the researchers report. Two of the four macaques survived largely symptom-free for about a year. About five months after the surgery she needed no additional insulin doses more.

The first two monkeys, the researchers overestimated the required suppression of the monkey immune system. An overdose of specific drugs, the rejection of the graft to prevent, in these animals led to early death, report Reisner and his colleagues. The other two animals, however, the lower drug doses had survived 280 or 393 days and produced the body's own insulin again. With a special test, the researchers demonstrated that this insulin actually tissue from the pigs came.

The embryonic donor organs showed an outstanding capacity to cope with the stress of the transplant to resist and to regenerate, the researchers emphasize. The hope of making a new therapy for diabetes. First, it is true, however, further investigations into the immune suppression, the required amount of donor material and methodology to optimize the implantation.

Reisner is also a scientific consultant and partner in the biotechnology company Tissera, which supported the work financially, and explained in accordance with the statutes of the journal financial interest in the work.